Adaptive Design Methods in Clinical Trials 2nd Edition by Shein-Chung Chow ebook

Name: Adaptive Design Methods in Clinical Trials 2nd Edition by Shein-Chung Chow ebook
SKU: 258402_7883503
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$16.99

Adaptive Design Methods in Clinical Trials 2nd Edition by Shein-Chung Chow By: Shein-Chung Chow Publisher: Chapman and Hall/CRC Print ISBN: 9781439839874, 1439839875 other ISBN: 9781439839881, 1439839883 Edition: 2nd Copyright year: 2011With new statistical and scientific issues arising in adaptive clinical trial design, including the U.S. FDA?s recent draft guidance, a new edition of one of the first books on the topic is needed. Adaptive Design Methods in Clinical Trials, Second Edition reflects recent developments and regulatory positions on the use of adaptive designs in clinical trials. It unifies the vast and continuously growing literature and research activities on regulatory requirements, scientific and practical issues, and statistical methodology. New to the Second Edition Along with revisions throughout the text, this edition significantly updates the chapters on protocol amendment and clinical trial simulation to incorporate the latest changes. It also includes five entirely new chapters on two-stage adaptive design, biomarker adaptive trials, target clinical trials, sample size and power estimation, and regulatory perspectives. Following in the tradition of its acclaimed predecessor, this second edition continues to offer an up-to-date resource for clinical scientists and researchers in academia, regulatory agencies, and the pharmaceutical industry. Written in an intuitive style at a basic mathematical and statistical level, the book maintains its practical approach with an emphasis on concepts via numerous examples and illustrations. Additional ISBNs 9781283596664|9781439839881, 1283596660|1439839883

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